I had the same basic problems with two Mk1's I gave my girlfriends two girls. I had to do a bios upgrade though a floppy on a usb floppy drive to update the bios to the vista bios. Windows 7 loaded fine, but some hardware didn't work. Once I updated and loaded the vista drivers for sound and video it worked fine. For hotkeys I used a newer toughbook model I think CF-19 driver for hotkey.
Just checked the Panasonic site and it will need the bios updated for vista like I did on the Mk1, never had to do it for the 74 Mk3/4 versions.
It won't let me put the updated links down.
Windows_Vista_Upgrade_Step-by-Step_Guide(CF-74mk1_2)_ver2.pdf [1.28 mb]
bios_74_2_r060257.exe [0.9 mbhttp://www.panasonic.com/business/tough ... nloads.asp
Just have to go to the main site, search all drivers, for mk2, then vista upgrade for the links page.